GIST PDX Models

While the genetic reasons behind imatinib acquired resistance in gastrointestinal stromal tumors (GIST) are well known, the development of new agents to overcome this resistance has been limited. This is due to a lack of preclinical models which fully recapitulate the complex interplay of KIT primary and secondary mutations seen in the clinical population. CrownBio provides the world’s most comprehensive panel of GIST patient-derived xenograft (PDX) models, ideal for the preclinical evaluation of novel therapies to circumvent imatinib resistance. More

Patient-derived xenografts (PDX) offer the most translational preclinical model for efficacy screening in cancer drug development. Derived directly from patient tumors and never adapted to grow in vitro, PDX models reflect the heterogeneity and diversity of the human patient population. PDX give you an accurate, predictive model of how your treatment will perform, well before entering into expensive clinical trials. CrownBio’s HuPrime® PDX collection well characterized for pathology, growth characteristics, and are also genetically/genomically annotated for gene expression, gene copy number, mutations, and fusions.

MODEL ID CANCER TYPE SUBTYPE models per page
GS11327 GIST GIST VIEW MODEL Details
GS11328 GIST GIST VIEW MODEL Details
GS11329 GIST GIST VIEW MODEL Details
GS11331 GIST GIST VIEW MODEL Details
GS11339 GIST GIST VIEW MODEL Details
GS11342 GIST GIST VIEW MODEL Details
GS11351 GIST GIST VIEW MODEL Details
GS11353 GIST GIST VIEW MODEL Details
GS11354 GIST GIST VIEW MODEL Details
GS11360 GIST GIST VIEW MODEL Details