Head and Neck Cancer PDX Models

Head and neck cancers are cancers which start in the organs of the head or neck such as mouth, throat, and lips. As with all cancer treatment development, a predictive preclinical model is needed for therapy evaluation. Patient derived xenograft (PDX) models present a true representation of the human heterogeneity and provide the most accurate approach to predicting an agent’s efficacy prior to entering the clinic. CrownBio has a large collection of head and neck cancer PDX models, including many with EGFR amplification. Learn more about these models in the following publication: Molecular pathology of patient tumors, patient derived xenografts and cancer cell lines.pdf More

Patient-derived xenografts (PDX) offer the most translational preclinical model for efficacy screening in cancer drug development. Derived directly from patient tumors and never adapted to grow in vitro, PDX models reflect the heterogeneity and diversity of the human patient population. PDX give you an accurate, predictive model of how your treatment will perform, well before entering into expensive clinical trials.

CrownBio’s HuPrime® PDX collection well characterized for pathology, growth characteristics, and are also genetically/genomically annotated for gene expression, gene copy number, mutations, and fusions.

MODEL ID CANCER TYPE SUBTYPE models per page
HN0366 Head and Neck Cancer HNSCC VIEW MODEL Details
HN0586 Head and Neck Cancer HNSCC VIEW MODEL Details
HN0626 Head and Neck Cancer HNSCC VIEW MODEL Details
HN0635 Head and Neck Cancer HNSCC VIEW MODEL Details
HN0696 Head and Neck Cancer HNSCC VIEW MODEL Details
HN1391 Head and Neck Cancer HNSCC VIEW MODEL Details
HN1420 Head and Neck Cancer HNSCC VIEW MODEL Details
HN1972 Head and Neck Cancer HNSCC VIEW MODEL Details
HN2167 Head and Neck Cancer HNSCC VIEW MODEL Details
HN2170 Head and Neck Cancer HNSCC VIEW MODEL Details