Breast Cancer Tumor Homograft Models

The development of novel therapeutics for breast cancer requires relevant preclinical models that feature organ and disease specific mutations while preserving a relevant TME. Our breast cancer tumor homografts originate from the MMTV-PyVT TG GEMM, which spontaneously develop mammary tumors. A subset of our model feature HER2 overexpression. Models can be established as standard subcutaneous or orthotopic variants, providing relevant TME and facilitating the formation of distant metastases.

MODEL CANCER TYPE ORIGINAL GEMM MUTATION models per page
mBR6004Breast CancerMMTV-PyVT TGVIEW MODEL
mBR6174Breast CancerMMTV-PyVT TGVIEW MODEL
mBR9013Breast CancerMMTV-Erbb2VIEW MODEL
mBR9026Breast CancerMMTV-Erbb2VIEW MODEL
mBR9027Breast CancerMMTV-Erbb2VIEW MODEL