Breast Cancer Tumor Homograft Models

The development of novel therapeutics for breast cancer requires relevant preclinical models that feature organ and disease specific mutations while preserving a relevant TME. Our breast cancer tumor homografts originate from the MMTV-PyVT TG GEMM, which spontaneously develop mammary tumors. A subset of our model feature HER2 overexpression. Models can be established as standard subcutaneous or orthotopic variants, providing relevant TME and facilitating the formation of distant metastases.

MODEL NUMBER ORIGINAL GEMM MUTATION # per page
mBR6004MMTV-PyVT TGCLICK TO VIEW
mBR6174MMTV-PyVT TGCLICK TO VIEW
mBR9013MMTV-Erbb2CLICK TO VIEW
mBR9026MMTV-Erbb2CLICK TO VIEW
mBR9027MMTV-Erbb2CLICK TO VIEW