Sarcoma Tumor Homograft Models

Sarcoma comprises of a diverse family of malignancies with many histological subtypes and molecular aberrations. However, first-line sarcoma treatment options are still limited to surgery and chemotherapy which remain mostly ineffective, necessitating novel treatment strategies. Our sarcoma tumor homografts preserve original GEMM tumor histo- and molecular pathology as well as a relevant TME and are ideally positioned to test novel cross reactive or surrogate agents as well as combination strategies with checkpoint inhibitors.

MODEL CANCER TYPE ORIGINAL GEMM MUTATION models per page
mSA6046SarcomaKras (G12D); P53-/-VIEW MODEL
mSA6048SarcomaKras (G12D); P53-/-VIEW MODEL
mSA6049SarcomaKras (G12D); P53-/-VIEW MODEL
mSA6055SarcomaKRAS (G12D); PtenFlox/FloxVIEW MODEL
mSA6084SarcomaKRAS (G12D); PtenFlox/FloxVIEW MODEL
mSA6105SarcomaPTENFlox/Flox; P53-/-VIEW MODEL
mSA6177SarcomaPtch1-/+; P53-/-VIEW MODEL
mSA6180SarcomaPtch1-/+; P53-/-VIEW MODEL
mSA6182SarcomaPtch1-/+; P53-/-VIEW MODEL
mSA9003SarcomaP53-/-VIEW MODEL