Sarcoma Tumor Homograft Models

Sarcoma comprises of a diverse family of malignancies with many histological subtypes and molecular aberrations. However, first-line sarcoma treatment options are still limited to surgery and chemotherapy which remain mostly ineffective, necessitating novel treatment strategies. Our sarcoma tumor homografts preserve original GEMM tumor histo- and molecular pathology as well as a relevant TME and are ideally positioned to test novel cross reactive or surrogate agents as well as combination strategies with checkpoint inhibitors.

MODEL NUMBER ORIGINAL GEMM MUTATION # per page
mSA6046Kras (G12D); P53-/-CLICK TO VIEW
mSA6048Kras (G12D); P53-/-CLICK TO VIEW
mSA6049Kras (G12D); P53-/-CLICK TO VIEW
mSA6055KRAS (G12D); PtenFlox/FloxCLICK TO VIEW
mSA6084KRAS (G12D); PtenFlox/FloxCLICK TO VIEW
mSA6105PTENFlox/Flox; P53-/-CLICK TO VIEW
mSA6177Ptch1-/+; P53-/-CLICK TO VIEW
mSA6180Ptch1-/+; P53-/-CLICK TO VIEW
mSA6182Ptch1-/+; P53-/-CLICK TO VIEW
mSA9003P53-/-CLICK TO VIEW