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Esophageal Cancer PDX Models

Esophageal cancer is the 6th most common cause of cancer-related deaths which drives a need for a better understanding of the underlying mechanisms behind the disease through preclinical models. Patient-derived xenograft (PDX) models provide a true representation of human heterogeneity and can be used to better understand these mechanisms in relation to the development of new therapies. Crown Bioscience has a large selection of well-characterized esophageal cancer PDX models, including models with EGFR amplification. More

PDX offer the most translational preclinical model for efficacy screening in cancer drug development. Derived directly from patient tumors and never adapted to grow in vitro, PDX models reflect the heterogeneity and diversity of the human patient population. PDX give you an accurate, predictive model of how your treatment will perform, well before entering into expensive clinical trials. Crown Bioscience's HuPrime® PDX models are well characterized for pathology, growth characteristics, and are also genetically/genomically annotated for gene expression, gene copy number, mutations, and fusions.

MODEL NUMBER CANCER TYPE CANCER SUBTYPE DESCRIPTION # per page
ES0026 Esophageal Cancer ESCC Multiple squamous cell carcinoma of esophagus, well-moderately differentiated, carcinoma in situ, tumor mass: 5cm x 5cm x 2cm, 2cm x 2cm x 1cm, 1.5cm x 1cm x 1cm. CLICK TO VIEW
ES0042 Esophageal Cancer ESCC Moderately-poorly differentiated squamous cell carcinoma CLICK TO VIEW
ES0110 Esophageal Cancer ESCC Squamous cell carcinoma from inferior part of esophagus and gastric cardia, grade II, fungating type, tumor mass: 7.5cm x 4cm x 2cm, infiltrating into serosa. No visible malignant cells adjacent to both stump. Regional LN: paraesophageal LN (0/7), left gastric LN (0/6), cardial LN (0/2), LN of lesser curvature (0/8). CLICK TO VIEW
ES0136 Esophageal Cancer ESCC Squamous cell carcinoma of middle thoracic part of esophagus, ulcerative type, poorly differentiated, tumor mass: 5.5cm x 6cm x 1.5cm, infiltrating fibrous membrane. No malignant cells adjacent to both stump. Regional LN: paratracheal LN (0/3), left gastric LN (0/4), carina of trachea LN (0/3), parathoracic duct LN (1/1). CLICK TO VIEW
ES0141 Esophageal Cancer ESCC Squamous cell carcinoma of middle thoracic part of esophagus, ulcerative type, grade II, tumor mass: 7cm x 2.5cm 1.5cm, infiltrating into deep muscular layer. No malignant cells adjacent to both stump. Regional LN: paraesophageal LN (0/3), left gastric LN (0/4), carina of trachea LN (0/3), right superior mediastinum LN (1/1), adjacent to tumor LN (0/1). CLICK TO VIEW
ES0147 Esophageal Cancer ESCC Squamous cell carcinoma of inferior thoracic part of esophagus, medullary type, grade III, tumor mass: 5cm x 4cm x 1.5cm, infiltrating fibrous membranes with massive necrosis. No malignant cells adjacent to both stump. Regional LN: paraesophageal LN (0/12), left gastric LN (0/1). CLICK TO VIEW
ES0148 Esophageal Cancer ESCC Squamous cell carcinoma of middle thoracic part of esophagus, medullary type with adeno-differentiation, grade III, tumor mass: 3cm x 2cm x 0.5cm, infiltrating superficial muscular layer.No malignant cells adjacent to superior stump, mild atypical hyperplasia of a little gland in mucosa of inferior stump. Regional LN: paraesophageal LN (0/2), left gastric LN (1/1). CLICK TO VIEW
ES0159 Esophageal Cancer ESCC Squamous cell carcinoma of superior thoracic part of esophagus (postradiotherapy), scirrhous type, grade II, tumor mass: 3.5cm x 1.5cm x 0.5cm. No malignant cells adjacent to both stump. Regional LN: paraesophageal LN (0/3), carina of trachea LN (0/8). CLICK TO VIEW
ES0168 Esophageal Cancer ESCC Squamous cell carcinoma of inferior thoracic part of esophagus, fungating type, grade II-III, tumor mass: 3cm x 2cm x 1cm, invaded superficial muscular layer. No malignant cells adjacent to both stumps. Regional LN: left gastric LN (3/3), paraesophageal LN (0/2). CLICK TO VIEW
ES0172 Esophageal Cancer ESCC Squamous cell carcinoma of middle thoracic part of esophagus, medullary type, grade II-III, tumor mass 5cm x 4cm x 1cm, infiltrating into deep muscular layer. No malignant cells adjacent to both stump. Regional LN: paraesophageal LN (1/5), left gastric LN (0/1). CLICK TO VIEW
ES0176 Esophageal Cancer ESCC Squamous cell carcinoma of middle thoracic part of esophagus, medullary type, grade II, tumor mass: 5cm x 3.5cm x 1cm, infiltrating fibrous membrane. No malignant cells adjacent to both stump. Regional LN: left gastric LN (0/2), paraesophageal LN (2/3), cardia of LN (1/2). CLICK TO VIEW
ES0178 Esophageal Cancer ESCC Squamous cell carcinoma of middle thoracic part of esophagus, medullary type, grade II, tumor mass: 3cm X 2.5cm X 1.8cm, infiltrating into fibrous membranes. No malignant cells adjacent to both stump. Regional LN: left gastric LN (2/2), paraesophageal LN (0/1) CLICK TO VIEW
ES0181 Esophageal Cancer Squamous cell carcinoma of inferior thoracic part of esophagus, ulcerative type CLICK TO VIEW
ES0183 Esophageal Cancer EAC Moderately-poorly differentiated adenocarcinoma CLICK TO VIEW
ES0184 Esophageal Cancer ESCC Squamous cell carcinoma of middle thoracic part of esophagus, medullary type, grade I-II, tumor mass: 3cm x 2.5cm x 1cm, infiltrating superficial muscular layer. No malignant cells adjacent to both stump. Regional LN: paraesophageal LN (0/4), left gastric LN (0/3), inferior carina of trachea LN (0/7). CLICK TO VIEW
ES0189 Esophageal Cancer ESCC Squamous cell carcinoma of middle thoracic part of esophagus, medullary type, grade II, tumor mass: 4cm x 3.5cm x 1cm, infiltrating fibrous membranes. No malignant cells adjacent to both stump. Regional LN: paraesophageal LN (0/5), left gastric LN (0/2), right superior mediastinum LN (3/3). CLICK TO VIEW
ES0190 Esophageal Cancer ESCC Squamous cell carcinoma of superior thoracic part of esophagus, medullary type, grade II, tumor mass: 6cm x 2.5cm x 2cm, infiltrating fibrous membranes. No malignant cells adjacent to both stump. Regional LN: paraesophageal LN (0/5), left gastric LN (0/3), carina of trachea LN (0/3). CLICK TO VIEW
ES0191 Esophageal Cancer ESCC Squamous cell carcinoma of middle thoracic part of esophagus, ulcerative type, grade II, tumor mass 5.5cm x 4.5cm x 0.8cm, infiltrating into fibrous membranes. No malignant cells adjacent to both stump. Regional LN: paraesophageal LN (0/4), left gastric LN (1/1), parathoracic duct LN (0/1). CLICK TO VIEW
ES0195 Esophageal Cancer ESCC Squamous cell carcinoma of middle thoracic part of esophagus, ulcerative type, grade II-III, tumor mass: 4cm x 3.5cm x 0.5cm, infiltrating fibrous membranes and nerve plexus. No malignant cells adjacent to both stump. Regional LN: paraesophageal LN (0/7), left gastric LN (0/3), carina of trachea LN (0/1). CLICK TO VIEW
ES0199 Esophageal Cancer ESCC Squamous cell carcinoma of middle thoracic part of esophagus, medullary type, grade III, tumor mass: 4.5cm x 4cm x 1cm, infiltrating into fibrous membranes. No malignant cells adjacent to both stump. Regional LN: left gastric LN (0/1), paraesophageal LN (0/1), inferior lung LN (0/3). CLICK TO VIEW

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