July 10, 2019
Synonyms: L-5178-Y-R, L5178Y-R, L5178YR, LYR L5178-R is a murine T cell lymphoma cell line established from a L5178 thymic lymphoma induced by methylcholanthrene in a DBA/2 mouse. The model is suitable for the evaluation of anti-cancer agent efficacy and PD effects. At CrownBio, the L5178-R model is available as both subcutaneous and systemic (i.v. injected) […]
July 10, 2019
Synonyms: EL-4, EL 4, E.L.4 EL4 is a mouse thymic lymphoma cell line established by the induction of 9, 10-dimethyl-1,2-benzanthracene (DMBA) in a C57BL mouse. This model can be used to assess I/O treatment efficacy and immuno-PD changes. At CrownBio, the EL4 model is offered subcutaneously as well as systemically (i.v. injected). E.G7-OVA, a derivative […]
July 10, 2019
The E.G7-OVA is a mouse lymphoma cell line derived by the electroporation of EL4 cells with a plasmid which carries a complete copy of chicken ovalbumin (OVA) mRNA. These cells synthesize and secrete OVA constitutively. C57BL/6N mice immunized with E.G7-OVA cells generate H-2Kb restricted cytotoxic lymphocytes specific for the OVA258-276 peptide(1). This model serves as […]
July 10, 2019
Synonym: A-20 The A20 cell line is a B cell lymphoma line derived from a spontaneous reticulum cell sarcoma found in an aged BALB/c mouse(1). The model is suited for the assessment of surrogate and cross-reactive I/O agent efficacy and immuno-PD effects. At CrownBio, the A20 model is offered as both subcutaneous and systemic (i.v. […]