Synonyms: B16/F1, B16 F1, B16F1
B16-F1 is a murine cell line of melanoma, which was derived from the pulmonary melanoma nodule from the first serial passage of B16-F0 parent cell line in C57BL/6 mice(1). The model is suited for the evaluation of anti-cancer immunotherapy efficacy and PD. At CrownBio, the B16-F1 model has been established as a subcutaneous model.
Response to Immune Checkpoint Inhibitors
(1) Fidler IJ. Biological behavior of malignant melanoma cells correlated to their survival in vivo. Cancer Res. 35: 218-224, 1975.