Synonyms: B16/F10, B16 F10, B16F10, B16 melanoma F10
B16-F10 is a mouse melanoma cell line, which was derived from the pulmonary melanoma nodule from the tenth serial passage of the B16-F10 parent cell line in C57BL/6 mice(1). The model is commonly used for the efficacy and PD evaluation of surrogate and cross-reactive I/O agents. At CrownBio, the B16-F10 model is offered as subcutaneous and metastatic models.
Response to Immune Checkpoint Inhibitors
(1) Fidler IJ. Biological behavior of malignant melanoma cells correlated to their survival in vivo. Cancer Res. 35: 218-224, 1975.