Model Information:

Synonyms: B16/F10, B16 F10, B16F10, B16 melanoma F10
B16-F10 is a mouse melanoma cell line, which was derived from the pulmonary melanoma nodule from the tenth serial passage of the B16-F10 parent cell line in C57BL/6 mice(1). The model is commonly used for the efficacy and PD evaluation of surrogate and cross-reactive I/O agents. At CrownBio, the B16-F10 model is offered as subcutaneous and metastatic models.

Summary

Cancer Type Melanoma
Subtype N/A
Mouse Strain C57BL/6
TMA TMA-CP-SY-008

Response to Immune Checkpoint Inhibitors

Additional Characteristics

(1) Fidler IJ. Biological behavior of malignant melanoma cells correlated to their survival in vivo. Cancer Res. 35: 218-224, 1975.