Model Information:
Adenocarcinoma of colon with part of mucinous adenocarcinoma, moderately differentiated. Tumor cells show columnar with circular or oval nuclear. The tumor forms tubular or nest structures and has an infiltrative growth pattern. Poors of mucin in glandular cavity may be seen. Regional LN: mesenteric LN (5/20).
Summary
| Cancer Type | Colorectal Cancer |
|---|---|
| Subtype | ADC, mucinous adenocarcinoma |
| Grade | NA |
| Stage | NA |
| Ethnicity | Asian |
| Gender | F |
| Age | 35 |
| Pathology Diagnosis | Adenocarcinoma of colon with part of mucinous adenocarcinoma, moderately differentiated. Tumor cells show columnar with circular or oval nuclear. The tumor forms tubular or nest structures and has an infiltrative growth pattern. Poors of mucin in glandular cavity may be seen. Regional LN: mesenteric LN (5/20). |
| Biopsy Site | Colon |
| Treatment History | NA |
| Pathology QC | Moderately differentiated tubular adenocarcinoma, with part of mucinous adenocarcinoma (P3) |
| Special Features | PTPRK-RSPO3 fusion, PIK3CA E545K |
| Mouse Strain | Balb/c nu |
| TMA | TMA-HP-CR-033 |
| Publication | Molecular pathology of patient tumors, patient derived xenografts and cancer cell lines; Wnt addiction of genetically defined cancers reversed by PORCN inhibition; Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates B-Catenin Signaling and Tumorigenesis in Multiple Cancer Types; Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function |
