The E.G7-OVA is a mouse lymphoma cell line derived by the electroporation of EL4 cells with a plasmid which carries a complete copy of chicken ovalbumin (OVA) mRNA. These cells synthesize and secrete OVA constitutively. C57BL/6N mice immunized with E.G7-OVA cells generate H-2Kb restricted cytotoxic lymphocytes specific for the OVA258-276 peptide(1). This model serves as a useful tool for the study of cancer immunology. At CrownBio, the E.G7-OVA model is available as both subcutaneous and systemic (i.v. injected) models. EL4, the parental model, is also available.
| Summary | |
|---|---|
| Cancer Type | Lymphoma |
| Subtype | N/A |
| Mouse Strain | C57BL/6N(H-26) |
| TMA | TMA-CP-SY-008 |
(1) Moore MW, et al. Introduction of soluble protein into the class I pathway of antigen processing and presentation. Cell 54: 777-785, 1988.