The E.G7-OVA cell line is a mouse lymphoma cell line created by introducing a plasmid containing the complete sequence of chicken ovalbumin (OVA) into electroporated EL4 cells, resulting in constitutive OVA synthesis and secretion. C57BL/6N mice immunized with E.G7-OVA cells exhibit H-2Kb restricted cytotoxic lymphocytes specific for the OVA258-276 peptide, making this model valuable for studying cancer immunology. Crown Bioscjence offers both subcutaneous and systemic (i.v. injected) models of E.G7-OVA, as well as the parental EL4 model.
Summary | |
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Cancer Type | Lymphoma |
Subtype | N/A |
Mouse Strain | C57BL/6N(H-26) |
TMA | TMA-CP-SY-008 |
(1) Moore MW, et al. Introduction of soluble protein into the class I pathway of antigen processing and presentation. Cell 54: 777-785, 1988.