Model Information:

Adenocarcinoma derived from juncture of stomach and esophagus in lesser gastric curvature, protrude, ulcerative type, poorly differentiated, tumor mass: 6cm x 5cm x 1.5cm. Malignant cells infiltrating into gastric wall and esophagus. Regional LN: LN of lesser curvature (3/14). IHC results: HER-1(+), HER-2(-), p53(+ 25~50%), p170(-),Ki-67(+, 25-50%), VEGF(++), Top-IIa(+ about 10%), p16(-).

Summary

Cancer Type Gastric Cancer
Subtype ADC
Grade III
Stage T4N1M0 III
Ethnicity Asian
Gender F
Age 74
Pathology Diagnosis

Adenocarcinoma derived from juncture of stomach and esophagus in lesser gastric curvature, protrude, ulcerative type, poorly differentiated, tumor mass: 6cm x 5cm x 1.5cm. Malignant cells infiltrating into gastric wall and esophagus. Regional LN: LN of lesser curvature (3/14). IHC results: HER-1(+), HER-2(-), p53(+ 25~50%), p170(-),Ki-67(+, 25-50%), VEGF(++), Top-IIa(+ about 10%), p16(-).

Biopsy Site Stomach
Treatment History NA
Pathology QC Moderately-poorly differentiated adenocarcinoma (P4). IHC (P5): TTF1 (-), CDX2 (3+), CK7 (+), CK20 (3+).
Special Features Cachexia, Metastatic (subC)
Mouse Strain Balb/c nu
TMA TMA-HP-GA-021
Publication A subset of gastric cancers with EGFR amplification and overexpression respond to cetuximab therapy; Stromal-Based Signatures for the Classification of Gastric Cancer

Growth Characteristics

Additional Characteristics