Model Information:

Adenocarcinoma derived from juncture of stomach and esophagus in lesser gastric curvature, protrude, ulcerative type, poorly differentiated, tumor mass: 6cm x 5cm x 1.5cm. Malignant cells infiltrating into gastric wall and esophagus. Regional LN: LN of lesser curvature (3/14). IHC results: HER-1(+), HER-2(-), p53(+ 25~50%), p170(-),Ki-67(+, 25-50%), VEGF(++), Top-IIa(+ about 10%), p16(-).

Summary

Cancer TypeGastric Cancer
SubtypeADC
GradeIII
StageT4N1M0 III
EthnicityAsian
GenderF
Age74
Pathology Diagnosis

Adenocarcinoma derived from juncture of stomach and esophagus in lesser gastric curvature, protrude, ulcerative type, poorly differentiated, tumor mass: 6cm x 5cm x 1.5cm. Malignant cells infiltrating into gastric wall and esophagus. Regional LN: LN of lesser curvature (3/14). IHC results: HER-1(+), HER-2(-), p53(+ 25~50%), p170(-),Ki-67(+, 25-50%), VEGF(++), Top-IIa(+ about 10%), p16(-).

Biopsy SiteStomach
Treatment HistoryNA
Pathology QCModerately-poorly differentiated adenocarcinoma (P4). IHC (P5): TTF1 (-), CDX2 (3+), CK7 (+), CK20 (3+).
Special FeaturesCachexia, Metastatic (subC)
Mouse StrainBalb/c nu
TMATMA-HP-GA-021
PublicationA subset of gastric cancers with EGFR amplification and overexpression respond to cetuximab therapy; Stromal-Based Signatures for the Classification of Gastric Cancer

Growth Characteristics

Additional Characteristics