Synonyms (of parental line): Glioma 261, GLIOMA 261, Glioma-261, GL-261
GL261 is a mouse glioblastoma cell line. The original tumor was induced by intracranial injection of 3-methylcholantrene into C57BL/6 mice(1). GL261 cells were transduced by firefly luciferase gene to generate the reporter line, GL261-luc for the monitoring of disease progression via bioluminescent imaging. The model is suitable for imaging studies and efficacy/PD testing. At CrownBio, the GL261-luc model is offered as both subcutaneous and orthotopic models.
Response to Immune Checkpoint Inhibitors