Hepa 1-6

Model Information:

Synonyms: HEPA 1-6, Hepa1-6
Hepa 1-6 is a murine model of hepatocellular carcinoma (HCC), derived from the BW7756 mouse hepatoma that spontaneously arose in a C57/L mouse(1). This cell line can be grown in the C57BL/6 mouse strain for in vivo testing. It is well-suited for evaulating the efficacy and immuno-PD changes following anti-cancer immunotherapy treatment. At CrownBio, the Hepa 1-6 model is available subcutaneously and orthotopically. In addition, a firefly luciferase tagged reporter line of Hepa 1-6 model is available, fascilitating disease progression tracking via bioluminescent imaging.

Cancer TypeLiver Cancer
Mouse StrainC57L

Response to Immune Checkpoint Inhibitors

Additional Characteristics

(1) Darlington GJ. Liver cell lines. Methods Enzymol. 151: 19-38, 1987.

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