Model Information:

The chimeric human/mouse PD-1 gene (h/mPD-1) consisting of human exon 2 which is “knock in” by using CRISPR/Cas9 technology to create homozygous h/mPD-1 HuGEMM C57BL/6 mice. This model is an appropriate platform for human anti-PD-1 antibody evaluation.

Summary

Type Single Knock-In
Target Human PD-1
Mouse Strain C57BL/6

Validation of Human Target Expression

Additional Characteristics