JC is a cell line of the malignant neoplasm of the mouse mammary gland. It is an epithelial-like cell line established from a spontaneous primary mammary adenocarcinoma along the milk line(1). The model offers a suitable platform for the efficacy and PD evaluation of single and combination I/O agent therapies. At CrownBio, the JC model is offered as a subcutaneous model in the flank.
|Cancer Type||Breast Cancer|
Response to Immune Checkpoint Inhibitors
(1) Characterization of a new spontaneously developed murine mammary adenocarcinoma in syngeneic BALB/c hosts. In Vitro Cell. Dev. Biol. 25: 621-626, 1989.