Model Information:

Synonyms: MC-38, MCA-38, MCA 38, MCA38, Mouse Colon 38, Murine Carcinoma-38, Colon 38, Colon-38, Colon38, C38
MC38 is derived from a colon tumor in a C57BL/6 mouse following long-term exposure to 1,2-dimethylhydrazine dihydrochloride (DMH)(1). It is one of the most popularly used models for assessing anti-cancer immunotherapies and is fit for evaluating the efficacy and PD effects. At Crown Bioscience, the MC38 cell line model is available as a subcutaneous model. A human PD-L1 knock-in model of MC38 is available for testing human-specific anti-PD-L1 antibodies.

Cancer TypeColorectal Cancer
Mouse StrainC57BL/6

Response to Immune Checkpoint Inhibitors

Additional Characteristics

(1) Corbett T.H., Griswold D.P. Jr., Roberts B.J., Peckham J.C., Schabel F.M. Jr. Tumor induction relationships in development of transplantable cancers of the colon in mice for chemotherapy assays, with a note on carcinogen structure. Cancer Res. 35:2434-2439, 1975.

Create HuBase Account to View All Model Data

Already Registered? Login