Model Information:

Synonyms: MC-38, MCA-38, MCA 38, MCA38, Mouse Colon 38, Murine Carcinoma-38, Colon 38, Colon-38, Colon38, C38
MC38 is derived from a colon tumor in a C57BL/6 mouse following long-term exposure to 1,2-dimethylhydrazine dihydrochloride (DMH)(1). It is one of the most popularly used model for the assessment of anti-cancer immunotherapies and is fit for the evaluation of efficacy and PD effects. At CrownBio, the MC38 model is available as a subcutaneous model. A human PD-L1 knock-in model of MC38 is available for testing human specific anti-PD-L1 antibodies.

Summary

Cancer Type Colorectal Cancer
Subtype N/A
Mouse Strain C57BL/6
TMA TMA-CP-SY-008

Response to Immune Checkpoint Inhibitors

Additional Characteristics

(1) Corbett T.H., Griswold D.P. Jr., Roberts B.J., Peckham J.C., Schabel F.M. Jr. Tumor induction relationships in development of transplantable cancers of the colon in mice for chemotherapy assays, with a note on carcinogen structure. Cancer Res. 35:2434-2439, 1975.