Synonyms: MC-38, MCA-38, MCA 38, MCA38, Mouse Colon 38, Murine Carcinoma-38, Colon 38, Colon-38, Colon38, C38
MC38 is derived from a colon tumor in a C57BL/6 mouse following long-term exposure to 1,2-dimethylhydrazine dihydrochloride (DMH)(1). It is one of the most popularly used models for assessing anti-cancer immunotherapies and is fit for evaluating the efficacy and PD effects. At Crown Bioscience, the MC38 cell line model is available as a subcutaneous model. A human PD-L1 knock-in model of MC38 is available for testing human-specific anti-PD-L1 antibodies.
|Cancer Type||Colorectal Cancer|
(1) Corbett T.H., Griswold D.P. Jr., Roberts B.J., Peckham J.C., Schabel F.M. Jr. Tumor induction relationships in development of transplantable cancers of the colon in mice for chemotherapy assays, with a note on carcinogen structure. Cancer Res. 35:2434-2439, 1975.