Model Information:
This strain carries a conditional mutant Kras (KrasLSL-G12D/WT) and a constitutive deletion of Trp53 (p53KO/KO). G12D mutant Kras was activated upon administrating adeno-cre to the lung by inhalation at 6 weeks of age, which resulted in lung cancer approximately 8 weeks later.
Summary
| Cancer Type | Lung Cancer |
|---|---|
| Mutations | Kras (G12D); P53-/- |
| Biopsy Site | Lung |
| Pathology QC | Poorly to moderately differentiated adenocarcinoma (Pa, P5) |
| Mouse Strain | C57BL/6 |
| TMA | TMA-MP-MX-001 |
