Model Information:

This strain carries a conditional mutant Kras (KrasLSL-G12D/WT) and a constitutive deletion of Trp53 (p53KO/KO). G12D mutant Kras was activated upon administrating adeno-cre to the lung by inhalation at 6 weeks of age, which resulted in lung cancer approximately 8 weeks later.


Cancer Type Lung Cancer
Mutations Kras (G12D); P53-/-
Biopsy Site Lung
Pathology QC Poorly to moderately differentiated adenocarcinoma (Pa, P5)
Mouse Strain C57BL/6

Growth Characteristics

Additional Characteristics