This strain carries a conditional mutant Kras (KrasLSL-G12D/WT) and a constitutive deletion of Trp53 (p53KO/KO). G12D mutant Kras was activated upon administrating adeno-cre to the lung by inhalation at 6 weeks of age, which resulted in lung cancer approximately 8 weeks later.
|Cancer Type||Lung Cancer|
|Mutations||Kras (G12D); P53-/-|
|Pathology QC||Poorly to moderately differentiated adenocarcinoma (Pa, P5)|