This model was developed from a tumor in the mesenteric lymph node of a C57BL/6 mouse carrying the Igh-Myc mutation. The primary tumor developed at ~13 weeks of age. Expression of the mouse Myc transgene is restricted to the B cell lineage. Hemizygotes show increased pre-B cells in the bone marrow throughout life and a transient increase in large pre-B cells in the blood at 3-4 weeks of age. Spontaneous pre-B and B cell lymphomas reach an incidence of 50% at 15-20 weeks in hemizygous progeny of a wildtype female mated with a hemizygous male.
Summary | |
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Cancer Type | Lymphoma |
Subtype | N/A |
Mutations | IgH-Myc TG (Eµ Myc) |
Biopsy Site | Mesentery |
Pathology QC | Burkitt's lymphoma (P4, Pa) |
Mouse Strain | C57BL/6 |