This strain carries a conditional mutant Kras (KrasLSL-G12D/WT), a constitutive deletion of Trp53 (p53KO/KO) and a Cre driven by the promoter of Pdx1 gene. The mouse developed a severe pancreatic tumor and was near death at the age of 8 weeks.
|Cancer Type||Pancreatic Cancer|
|Mutations||KRAS (G12D); P53-/-;PDx-1 cre|
|Pathology QC||Moderately differentiated adenocarcinoma (P6, Pa)|
|Publication||Immunophenotyping of Orthotopic Homograft (Syngeneic) of Murine Primary KPC Pancreatic Ductal Adenocarcinoma by Flow Cytometry|