Model Information:

This strain carries a conditional mutant Kras (KrasLSL-G12D/WT), a constitutive deletion of Trp53 (p53KO/KO) and a Cre driven by the promoter of Pdx1 gene. The mouse developed a severe pancreatic tumor and was near death at the age of 8 weeks.

Summary

Cancer Type Pancreatic Cancer
Mutations KRAS (G12D); P53-/-;PDx-1 cre
Biopsy Site Pancreases
Pathology QC Moderately differentiated adenocarcinoma (P6, Pa)
Mouse Strain C57BL/6
Publication Immunophenotyping of Orthotopic Homograft (Syngeneic) of Murine Primary KPC Pancreatic Ductal Adenocarcinoma by Flow Cytometry

Growth Characteristics

Additional Characteristics