Model Information:

This strain carries a conditional mutant constitutive deletion of Trp53 and conditional knock out of PTEN (PTENflox/flox). PTEN was knocked out upon injecting adeno-cre to the prostate at 6 weeks of age, which resulted in a prostate tumor ~4 months later.


Cancer TypeProstate Cancer
MutationsPTENFlox/Flox; P53-/-
Biopsy SiteProstate
Pathology QCLipoSA-Sarcoma (P2)
Mouse StrainC57BL/6

Growth Characteristics

Additional Characteristics