Model Information:

This model was developed from a spontaneous tumor located in the left flank of a C57BL/6 mouse with a Trp53 deletion. The primary tumor developed at approximately 18 weeks of age.

Summary

Cancer Type Sarcoma
Mutations P53-/-
Biopsy Site Forsal side of foreleg
Pathology QC Malignant peripheral nerve sheath tumor (P1)
Mouse Strain C57BL/6
Publication Niraparib activates interferon signaling and potentiates anti-PD-1 antibody efficacy in tumor models

Growth Characteristics

Additional Characteristics