This model was developed from a subcutaneous primary tumor in a C57BL/6J mouse carrying the ApcMin mutation. This strain is highly susceptible to spontaneous intestinal adenoma formation.
|Cancer Type||Skin Cancer|
|Biopsy Site||Forsal side of foreleg|
|Pathology QC||Well differentiated squamous cell carcinoma (P0)|
|Publication||Niraparib activates interferon signaling and potentiates anti-PD-1 antibody efficacy in tumor models|
|Reference||A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse|