Synonyms: N1E115, NIE-115, NIE 115
N1E-115 is a murine neuroblastoma cell line, which was established by cloning the C-1300 spontaneous mouse neuroblastoma tumor(1). The model can be used to evaluate the efficacy and immuno-PD of surrogate and cross-reactive I/O agents in A/J mice. At CrownBio, the N1E-115 model is offered subcutaneously.
Response to Immune Checkpoint Inhibitors
(1) Amano T, et al. Neurotransmitter synthesis by neuroblastoma clones (neuroblast differentiation-cell culture-choline acetyltransferase- acetylcholinesterase-tyrosine hydroxylase-axons-dendrites). Proc. Natl. Acad. Sci. USA 69: 258-263, 1972.