Synonyms: Panc02, Panc-02, PAN 02, Panc02-H0
Pan02 is a well-established mouse pancreatic ductal adenocarcinoma (PDAC) model developed by chemical induction with 3-methylcholanthrene (3-MCA)(1). The cell line can be grown in the C57BL/6 mouse strain for in vivo testing. The relatively slow tumor growth of this model enables for ample treatment window, making this the ideal model for the evaluation of anti-cancer immunotherapy response and pharmacodynamics of the immune system. At CrownBio, the Pan02 model is available subcutaneously as well as orthotopically. In addition, a firefly luciferase tagged reporter line of Pan02 model is available, fascilitating disease monitoring via bioluminescent imaging.
|Cancer Type||Pancreatic Cancer|
Response to Immune Checkpoint Inhibitors
(1) Corbett TH, Roberts BJ, Leopold WR, Peckham JC, Wilkoff LJ, Griswold DP Jr, Schabel FM Jr. Induction and chemotherapeutic response of two transplantable ductal adenocarcinomas of the pancreas in C57BL/6 mice. Cancer Res. 44:717-726, 1984.