Prostate Cancer PDX Models

Suitable preclinical models such as Patient derived xenografts (PDX) are needed to evaluate drugs specifically targeting prostate cancer and have historically been difficult to generate due to the benign nature of this disease and the difficulty in propgating the model. Despite these challenges, CrownBio offers a collection of prostate cancer PDX models featuring tumor material diagnosed based on operative pathology and immunohistochemistry (IHC) focused on prostate specific markers e.g. PSA and androgen receptor expression. More

Patient-derived xenografts (PDX) offer the most translational preclinical model for efficacy screening in cancer drug development. Derived directly from patient tumors and never adapted to grow in vitro, PDX models reflect the heterogeneity and diversity of the human patient population. PDX give you an accurate, predictive model of how your treatment will perform, well before entering into expensive clinical trials. CrownBio’s HuPrime® PDX collection well characterized for pathology, growth characteristics, and are also genetically/genomically annotated for gene expression, gene copy number, mutations, and fusions.

MODEL ID CANCER TYPE SUBTYPE models per page
PR6511 Prostate Cancer CRPC VIEW MODEL Details
PR6512 Prostate Cancer CRPC VIEW MODEL Details